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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CISH
All Species:
31.21
Human Site:
S136
Identified Species:
68.67
UniProt:
Q9NSE2
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NSE2
NP_037456.5
258
28663
S136
V
R
I
E
Y
A
D
S
S
F
R
L
D
S
N
Chimpanzee
Pan troglodytes
XP_526202
462
50560
S340
V
R
I
E
Y
A
D
S
S
F
R
L
D
S
N
Rhesus Macaque
Macaca mulatta
XP_001097824
258
28705
S136
V
R
I
E
Y
A
D
S
S
F
R
L
D
S
N
Dog
Lupus familis
XP_541873
376
41170
S255
V
R
I
E
Y
A
D
S
S
F
R
L
D
S
N
Cat
Felis silvestris
Mouse
Mus musculus
Q62225
257
28518
S136
V
R
I
E
Y
A
D
S
S
F
R
L
D
S
N
Rat
Rattus norvegicus
O70512
256
28380
S135
V
R
I
E
Y
A
D
S
S
F
R
L
D
S
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513494
261
29787
S145
V
R
I
E
Y
A
D
S
K
F
R
L
D
S
N
Chicken
Gallus gallus
Q9PW70
249
28100
S138
V
R
I
E
Y
A
D
S
K
F
R
L
D
S
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070085
212
23910
Q104
N
V
R
I
E
Y
R
Q
C
R
F
S
L
D
S
Tiger Blowfish
Takifugu rubipres
NP_001107630
214
24036
L106
Y
S
R
G
S
F
W
L
D
S
I
A
A
G
Q
Fruit Fly
Dros. melanogaster
Q08012
211
24417
G103
L
S
V
K
C
P
D
G
V
Q
H
F
K
V
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
55.6
96.5
62.2
N.A.
90.6
89.9
N.A.
67
67
N.A.
41
37.6
22
N.A.
N.A.
N.A.
Protein Similarity:
100
55.6
97.2
63.5
N.A.
92.2
91.4
N.A.
76.6
75.9
N.A.
54.6
48.8
34.8
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
N.A.
0
0
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
N.A.
6.6
0
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
73
0
0
0
0
0
10
10
0
0
% A
% Cys:
0
0
0
0
10
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
82
0
10
0
0
0
73
10
0
% D
% Glu:
0
0
0
73
10
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
10
0
0
0
73
10
10
0
0
0
% F
% Gly:
0
0
0
10
0
0
0
10
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% H
% Ile:
0
0
73
10
0
0
0
0
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
10
0
0
0
0
19
0
0
0
10
0
0
% K
% Leu:
10
0
0
0
0
0
0
10
0
0
0
73
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
73
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
10
% Q
% Arg:
0
73
19
0
0
0
10
0
0
10
73
0
0
0
0
% R
% Ser:
0
19
0
0
10
0
0
73
55
10
0
10
0
73
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
73
10
10
0
0
0
0
0
10
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
73
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _